Role of hepatobiliary scintigraphy with different semi-quantitative parameters along with histopathological scoring in differentiating biliary atresia from neonatal hepatitis

Abstract Background Biliary atresia (BA) and neonatal hepatitis (NH) are the two major causes of cholestasis (NC). However, both conditions had entirely different therapeutic schedule prognosis. Considering BA as a surgical emergency, it is pretty important to accurately differentiate entities. The aim study evaluate diagnostic utility hepatobiliary scintigraphy (HBS) using semi-quantitative technique well 15-point histopathological scoring system in differentiating from NH. Results sensitivity, specificity, overall accuracy HBS diagnosis was 90.5%, 80%, 83.6%, respectively. median values kidney-liver ratio (KLR), intestinal-liver (ILR), background-liver (BLR) were significantly higher patients with BA, while that liver-kidney (LKR) lower cases BA. Moreover, KLR largest area under curve (AUC); advocates be best parameters can predicts Histopathological cutoff point ≥ 7 helpful discriminating NH 85.7% 95% specificity 91.8% accuracy. Conclusions non-invasive tool frequently used yet has relatively low specificity. To overcome this challenge, we kindly recommend use could possibly improve for diagnosing Additionally, liver biopsy useful.